品牌 | SOLARBIO/索萊寶 | 貨號 | K107500P |
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規(guī)格 | 50ul/100ul | 供貨周期 | 現(xiàn)貨 |
主要用途 | WB IHC | 應用領(lǐng)域 | 醫(yī)療衛(wèi)生,環(huán)保,化工,生物產(chǎn)業(yè),農(nóng)業(yè) |
Anti-RPA2 Polyclonal Antibody
宿主 | Rabbit |
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英文名稱 | Anti-RPA2 Polyclonal Antibody |
別名 | REPA2;RP-A p32;RP-A p34;RPA32;RP-Ap32;RP-Ap34;replication protein A2 |
應用 | WB IHC |
稀釋比例 | WB 1:5000-8000. IHC 1:50-200. |
蛋白分子量 | 29/38kDa |
保存 | Store at -20°C. Avoid freeze / thaw cycles. |
儲存液 | Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. |
純化方法 | Affinity purification |
亞型 | IgG |
免疫原 | A synthetic peptide of human RFA2 |
Swiss Prot | P15927 |
Subcellular Locations | Nucleus Cytoplasm |
克隆類型 | Polyclonal Antibody |
背景資料 | As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. In the cellular response to DNA damage, the RPA complex controls DNA repair and DNA damage checkpoint activation. Through recruitment of ATRIP activates the ATR kinase a master regulator of the DNA damage response. It is required for the recruitment of the DNA double-strand break repair factors RAD51 and RAD52 to chromatin in response to DNA damage. Also recruits to sites of DNA damage proteins like XPA and XPG that are involved in nucleotide excision repair and is required for this mechanism of DNA repair. Plays also a role in base excision repair (BER) probably through interaction with UNG. Also recruits SMARCAL1/HARP, which is involved in replication fork restart, to sites of DNA damage. May also play a role in telomere maintenance. |
多克隆抗體
由于多克隆抗體通常包含抗某一抗原的不同表位的抗體,所以,在深固定的樣本中也會很好地發(fā)揮效應,在石蠟包埋組織切片的染色中,多克隆抗體常選用。根據(jù)實驗的不同需要,多克隆抗體應用于相應抗原的標記。此外,在農(nóng)業(yè)生產(chǎn)中,多克隆抗體被用于農(nóng)藥殘留現(xiàn)場監(jiān)測;在臨床應用中,多克隆抗體主要用于病原物的檢測、疾病的診斷及治療,如作為蛋白類免疫抑制劑用于移植反應和自身免疫病的治療。
索萊寶公司創(chuàng)立于2004年是一家擁有大批專業(yè)研發(fā)人員,專注于生物產(chǎn)品不斷完善和創(chuàng)新的公司。我們產(chǎn)品覆蓋面廣,品質(zhì)可靠。在優(yōu)化試劑產(chǎn)品線的同時,經(jīng)過多年研發(fā)經(jīng)驗的積累,也推出了新的抗體產(chǎn)品線。初期,大批科研人員精心設計,齊力設計出好的抗體產(chǎn)品;后期,質(zhì)檢工作者嚴格的質(zhì)量把控為我們保駕護航。終,在我們的共同努力之下,帶您見證索萊寶公司的又一奇跡。
運輸說明:
極低溫產(chǎn)品:極低溫產(chǎn)品運輸過程中加裝干冰運輸。用干冰把產(chǎn)品包裹起來,再用泡沫盒密封,膠帶層層粘住泡沫盒,放入索萊寶的箱子,然后交付給合作快遞,安全快速高效放心的送客戶的手中,保證產(chǎn)品的性質(zhì)穩(wěn)定如一,為您的實驗保駕護航。
低溫產(chǎn)品:低溫產(chǎn)品運輸過程中加裝索萊寶冰袋運輸。事先用冰袋把產(chǎn)品包裹起來,再使用泡沫盒密封,用膠帶嚴實密封泡沫盒,再放入索萊寶的箱子(保溫效果少可以持續(xù)一周),然后交付給合作快遞,安全快速高效放心的送客戶的手中,保證產(chǎn)品的性質(zhì)穩(wěn)定如一,為您的實驗保駕護航。
常溫產(chǎn)品:常溫產(chǎn)品運輸過程中無需加冰或者特殊包裝。產(chǎn)品由公司庫房人員快速配貨,準確快速高效的快遞保證產(chǎn)品快速送達您的手中。